Recombinant Onco BCG
Publications and patents
Publications:
Chade DC, Borra RC, Nascimento IP, Villanova FE, Leite LC, Andrade EF, Ramos K, Srougi M, Andrade PM. Immunomodulatory effects of recombinant BCG expressing pertussis toxin on TNF-alpha and IL-10 in a bladder cancer model. J Exp Clin Cancer Res 27, 78, 2008. doi: 10.1186/1756-9966-27-78
Andrade PM, Chade DC, Borra RC, Nascimento IP, Villanova FE, Leite LC, Andrade E, Srougi M. The therapeutic potential of recombinant BCG expressing the antigen S1PT in the intravesical treatment of bladder cancer. Urol Oncol. 28(5): 520-5, 2010. doi: 10.1016/j.urolonc.2008.12.017
Rodriguez, D, Goulart, C, Pagliarone, AC, Silva, E, Cunegundes, P, Nascimento, IP, Borra, RC, Dias, WO, Tagliabue, A, Boraschi, D, Leite, LCC, In vitro evidence of human immune responsiveness shows the improved potential of a recombinant BCG strain for bladder cancer treatment, Frontiers in Immunology, 2019, 10, 1460. doi: 10.3389/fimmu.2019.01460
Patent:
Leite, LCC, Nascimento, IP, Borra, PMA, Chade, DC, Borra, RC, Villanova, FE, Andrade, EFM, Srougi, M, Raw, I, 2009, Solicitação de pedido de invenção no Brasil (INPI), “Imunoterápico, composição farmacêutica, e uso de imunoterápico para manufatura de medicamento para uso no tratamento de câncer”, processo INPI nº 020090094393, Outubro 7, 2009. Approved.
Tuberculosis vaccine
Publications and patents
Publications:
Nascimento IP, Rodriguez D, Santos CC, Amaral EP, Rofatto HK, Junqueira-Kipnis AP, Gonçalves EDC, D'Império-Lima MR, Hirata MH, Silva CL, Winter N, Gicquel B, Mills KHG, Pizza M, Rappuoli R, Leite LCC. Recombinant BCG Expressing LTAK63 Adjuvant induces Superior Protection against Mycobacterium tuberculosis. Sci Rep. 2017, 7(1): 2109. doi: 10.1038/s41598-017-02003-9.
Santos, CC, Rodriguez, D, Kanno AI , Leite, LCC & Nascimento, IP (2019): Recombinant BCG expressing the LTAK63 adjuvant induces increased early and long-term immune responses against Mycobacteria, Hum Vaccin Immunother. 2020;16(3):673-683. doi:10.1080/21645515.2019.1669414.
Patents:
1. Leite, LCC, Nascimento, IP “Cepa de Mycobacterium bovis, Bacilus Calmette Guerin (BCG), Recombinante, composição imunogênica e uso” processo INPI nº 020120037904, Feb 17, 2012. Situation: Pendent.
Patent internationalization - PCT for:
1.1. Leite, LCC, Nascimento, IP “Recombinant strain of Mycobacterium bovis Bacilus Calmette Guerin (BCG), immunogenic composition and use” United States Patent No.: US 9,512,186 B2 Date Dec 6, 2016.
1.2. Leite, LCC, Nascimento, IP “Recombinant strain of Mycobacterium bovis Bacilus Calmette Guerin (BCG), immunogenic composition and use” Republic of South Africa Patent Office No.: 2014/06437 Date Mar 30, 2016.
1.3. Leite, LCC, Nascimento, IP “Recombinant strain of Mycobacterium bovis Bacilus Calmette Guerin (BCG), immunogenic composition and use” China Patent Office No.: 2014/06437 Date Feb 27, 2018.
2. Leite, LCC, Kanno, AI, Moraes, L, “Processo para construção de um único vetor compreendendo Cas9 e sgRNA para modificações do genoma de micobactérias”, INPI Processo no BR 10 2020 026128 2, Dec 18, 2020, Pendent.

